Press "Enter" to skip to content

Gladstone Researchers Gain New Understandings Into The Aging Brain

The protein klotho has been revealed to support longevity and counter aging-related impairments. Peculiarly, within the brain, choroid plexus encloses vastly high klotho levels compared to all the others.

Researchers at the Gladstone Institutes, directed by Lennart Mucke, MD, settled to probe why the choroid plexus holds so much more klotho compared to other regions in the brain. In a new research, they demonstrated that klotho works as a gatekeeper that protects the brain against the peripheral immune system.

In mouse models, the researchers said that they found that levels of klotho in the choroid plexus reduce naturally with age. They then imitated this aging process by decreasing klotho levels experimentally in this structure, and discovered that reducing this molecule augments brain inflammation.”

Further, the researchers examined the influence of this phenomenon on other areas in the brain. They found that in an animal model with less klotho within the choroid plexus, the innate immune cells within a significant memory center responded more assertively when other body parts were rendered to immune challenges that imitate infections.

The researchers state that the barrier between the immune system and brain appears to collapse with low klotho levels. Further, the results specify that klotho assists in keeping that barrier sealed. When this molecule’s levels are reduced within the choroid plexus, the fence becomes more permeable and facilitates inflammatory molecules and immune cells enter within more easily.”

Likewise, another recent study proposes that an immune reaction within the brains of strained mothers might assist in explaining postnatal depression cases. New proof from animal studies has related postnatal depression to inflammation in brain’s mood-regulating regions.

Researchers consider the findings can assist them to resolve the obscurity of the distressing condition that is still poorly comprehended. The study concentrated on the medial prefrontal cortex, the brain’s mood-regulating area earlier shown to be associated with postnatal depression.